Thursday, September 12, 2013

          The Center for Drug Evaluation (CDER) within the U.S. Food and Drug Administration (USFDA), invited Lenox Laser to participate in a conference in October of 2012 in recognition of the calibrated leak standard maintained by Lenox Laser in the pharmaceutical, medical, and food industries.
           Joseph d'Entremont and Gregory Solyar presented the following presentation at this conference, securing the foundation of Lenox Laser Medical, LLC as an organization born out of Lenox Laser Inc. that is dedicated to precision, accuracy, and service in the most dynamic health industries. 

 Producing a Calibrated Leak Standard with Laser Technology
Gregory Solyar
Scientist, Lenox Laser

OCBQ seminar: Current Technology in Container/Closure Testing

 Three Parts of Integrity Testing by Calibrated Orifice
     Manufacturing the leak

     Calibrating the leak

     Cross calibrating the leak test methods

Sealed and Filled Containers

 Open Containers



      Calibrating the leak measuring the flow and flow effective diameter

      Flow effective diameter the diameter of the round orifice with the area equivalent to a leak

      Positive, negative, volumetric flow meters

      Aspect ratio length of the channel divided by its diameter

      Laser parameters wavelength, energy per pulse, repetition rate, pulse width

      SEM (Electron Scanning Microscope)

Two Major Parts of Manufacturing the Leak

     Laser drill the orifice with post measurement

      (non-destructive and destructive)

     Laser drill the orifice with in-process test

 Pre-qualification of Containers: Syringes, Ampoules and Vials for Laser Drilling
       Measurement of the wall thickness deviation

       Selecting the methods of preprocessing (mechanical, laser beam)

       Optimizing the laser parameters for material composition

       Selecting the metrology methods for different contents of the containers (developing the repeatability, non-destructive and destructive methods)

       Selecting the correct methods and ways of handling: mechanical fixtures for drilling, marking, testing, storing, shipping

 Measurement of the Wall Thickness Deviation (Fig.1)
        The thickness of the material (glass, plastic) varies in different parts of the given container such as ampoule, syringe and bottle.

         Although this thickness is defined on the drawings of the manufacturer of the given containers, it may vary by 50%.

        The diameter of the microhole is effected by this thickness variation.

        Therefore, Lenox Laser performs its own study of the thickness in the areas selected for drilling by customer. Sometimes these methods are destructive.

Measurement of the Wall Thickness Deviation (Fig.2)

Measurement with OGP

Selecting the Methods of Preprocessing

       Due to high precision and aspect ratios, (ratio of a wall thickness to an orifice diameter), application of more than one laser beam is required. This step may also include some mechanical drilling before the application of the final laser beam for the calibrated orifice is done.

Optimizing the Laser Parameters for Material Composition

       Different types of glass or plastic have different thermal, mechanical and optical properties. Some of those types are very sensitive to changes of the laser parameters such as wavelength, energy per pulse, repetition rate, pulse width etc.

       Choice of the correct combination of the laser parameters may lead to cracking, melting, carbonization, separation of the composite materials, or the presence of micro-particles in a channel.

      Selecting the Metrology
Methods for Different Contents of the Containers

  The containers supplied for the orifice manufacturing may be empty or filled with liquid. The containers also may be open to the ambient atmosphere or sealed, having the internal pressure above or below ambient.

        In each particular case, one or more hole calibration methods may be used.

        The methods include:

        1. Mass flow, volumetric methods (volume vrc. time).

        Standard: leak standard.

        2. Optical microscope method (geometrical size and shape).

        Standard: optical standard.

        3. SEM method (geometrical size and shape on nano scale). Standard:  nano sphere.

        4. Bubble detection. Qualitative method.

 Mass Flow Methods

Flow Measuring Method by Water Displacement

Vacuum Gauges Calibration Station

 Flow Measurement by Vacuum Gauges

 Measurement by SEM

 Measurement by Electron Scanning Microscope

 Diffraction by the Orifices


Mechanical Fixtures for Laser Drilling under Flow Testing

Selecting the Correct Methods and Ways of Handling
         Due to a small diameter of the orifice, specific methods preventing the drilled channel from being clogged are applied.

         During processing, a presence of the assist gas or clean air and a method assuring the transport of the laser-created material particles away from a drilled sample may be necessary.

         The samples have individual reports indicating the effective flow diameter, or optical diameter, flow rate and test conditions. So correct identification of each sample container becomes very important. No marking on a sample itself is usually allowed.

         In case the containers are filled, Lenox Laser develops a specific method of packing with each customer to preserve the contents from contamination and the drilled channel from clogging.

 Goals and Vision
      Zero defects practice (aerospace philosophy)

      Use of the simplest possible methods and “transparent” physics for manufacturing.

      Use “optical signature” methods such as photography and videography on macro- and micro- scale for quality control and manufacturing.

      Develop new “Object oriented” methods and techniques for metrology.

Monday, June 13, 2011

Developing a Hybrid Neuroprosthesis for Epilepsy Treatment


Developing A Hybrid Neuroprosthesis For Epilepsy Treatment: A Status Report

By Nandor Ludvig, M.D.

Check out this article from 2004 on the following link below. The author collaborated with Lenox Laser in the research and development.

Tuesday, June 7, 2011

Industrial Applications

Industrial process instrumentation and control applications include metered multi-orifice oriented or omni-directional high-pressure spray delivery of liquids and gases into a process fluid flow. In-line chemical reactant control and post-combustion pollution control are reasonable uses for this device. Multiple inlet ports provide a means for flow-controlled pre-mixing of injected fluid, and allow the controlled internal mixing of gas and liquid prior to external delivery.

The Lenox Laser Diffuse Injector

The Lenox Laser diffuse injector is a fluidic device consisting of a tube with a sealed tip embedded with a geometric array of multiple uniform laser-drilled perforations of controlled dimension. Liquid and /or gas is supplied by a pump or syringe under pressure to the open ports at the supply end of the tube, and is then forced out through the perforations to the surrounding environment.

Thursday, May 26, 2011

Diffuse Injector For Therapeutic And Dye Delivery

Unlike an open hypodermic needle, fluid may be delivered to a volume of tissue surrounding the injector tip in many tiny increments, rather than a single large, mechanically traumatic bolus. For example, a 2-mm cylindrical active area on a 33-gauge diffuse injector typically provides 800 perforations of 10-um diameter on 25-um centers. An injected total volume of 1 ml delivers 1.25 ul from each perforations, reducing the likelihood of fluidic damage to surrounding tissue while delivered the fluid infiltrate. In research applications, typical syringe pumps are capable of 10^6: 1 dynamic range of volumetric delivery flow rate. This device allows a researcher to utilize more of that dynamic range without compromising adjacent tissue.

Thursday, December 16, 2010


In order to meet the high quality standards expected from our customers, Lenox Laser now offers a vacuum packing service to further ensure the integrity of manufactured parts from our facility to their intended destination.

Vacuum packing offers a wide range of advantages especially for those parts that require certain controlled conditions, such as, moisture-free or dust-free environments. Vacuum packing also reduces part movement in transit. Part movement or improperly packaged parts compromise a part’s integrity. This service may be of interest to our international customers whose parts must travel great distances.

Whether it is a single part or several, this vacuum packing service is highly recommended for our customers in the pharmaceutical, semiconductor and optical industries.

Call 1-800-49HOLES (4-6537) or email for more information. Be sure to visit our website at to view our line of parts and services.

Monday, June 22, 2009

Non-Restrictive Microperfusion Probe

The Lenox Laser Corporation has released the Non-Restrictive Microperfusion Probe for nano/micro-liter fluid sampling and delivery. The NRMP is a closed-end thin wall #304 stainless steal needle with a cylindrical array of laser drilled apertures having effective diameters of 10 microns. The NRMP is available in 27, 38, 30 and 33 gauge needles - each having a total aperture area equal to the cross-section area of the tubing. This provides the user with the ability to extract or deliver fluid without generating a large pressure gradient at the point of application. Probes are available in lengths of 25mm to 75mm. Custom perforation arrays (up to 1000 holes) having aperture diameters from 5 to 20 microns are also available (Luer tubing connectors are optional).